と違って => different to N2
Compare
に相違ない => without a doubt; certain; sure N2
に[相違「そうい」]ない => No doubt N2
Information, Report
に[違「ちが」]いない => Without a doubt, A N2
Information, Report
~ といっても間違いない => although I say; although one might say ~ it doesn't matter ... N1
Explain