それでは => Well then N4
Change the subject of the story
それでは => So (Inference) N4
Deduce
それは => That/That's it N4
それはそうと => anyway N2
~はどう(で)あれ      => however; whatever​ ~. N1
これいじょう…は ... => No... more N2
Limit, limit
それにしては => yet, notwithstanding, nevertheless N2
Things do not match the prediction
それでは => If so, then (result with negative connotation) N4
Change the subject of the story
それでは => In that case..., so... (Expressing an attitude) N4
Change the subject of the story
これでは => If so, Well (then), In that case N2
Evaluate
それはそうと => By the way N2
Miscellaneous
ではいられない => can't afford to; unable to N2
Base, base