切る => Give up, stop... N3
Happens next
切る/切れる/切れない => to do something completely to the end/unable to do; too much to finish/complete N3
~をかわきりに(~を皮切りに)      => One after another; starting with ~ N1
抜きにして/ 抜きにしては~れない => without; leaving out; cutting out ~ N2
なけりゃ => If not ... N2
Condition (hypothetical condition)
抜きで => without; leaving out; cutting out ~ N2
Attached
...かける => Impact N3
Act
とりわけ => especially; above all ~ N3
Emphasis on degree
抜く => to do something from beginning to end N2
[切「き」]れない => Can't finish/complete A N3
Potential, Possibility
抜きに...れない => without; leaving out; cutting out ~ N2
Conditions (necessary conditions)
... を抜きにしては => If it weren't for… N2
Confirm