に[先立「さきだ」]って/に[先立「さきだ」]ち/に[先立「さきだ」]つ => Before A occurs/takes place N2
Time, Situation
に先立って => before; prior to ~ N2
[気味「きみ」]だ => Like A, Looking like A (is happening) N2
Adjectival, Descriptions
ときているから/ときているので => because of ~ N1
... を抜きにしては => If it weren't for… N2
Confirm
ときている => Because of A N1
Reason, Result, Response
~をたて(~を経て)      => through; after; via N1
気味 => -like; -looking; -looked; tending to ~ N2
~をかわきりに(~を皮切りに)      => One after another; starting with ~ N1
~むきがある(~向きがある)     => There is a tendency N1
をかわきりに => Starting with A N1
Miscellaneous
を[機「き」]に => Use A as an opportunity N1
Time, Situation