にかけては => When it comes to A N2
Considering, Concerning
てはいけない => May not A, must not A N4
Can, Should, Must
わけにはいかない => Must not A, Must A N3
Needs, Requirement
なくてはいけない => Must do A; have to A N4
Can, Should, Must
だけではすまない => Doing A is not going to suffice N1
Miscellaneous
わけではない => Although you may think A, that is not the case. N3
Contrast
それはそうと => By the way N2
Miscellaneous
なければならない => Must do A; have to A N4
Can, Should, Must
ずにはいられない/ないではいられない => Can't help but A; A is unavoidable N2
Will, Decision, “Doing”
だけのことはある => It's not surprising that A, A is no surprise, A is no wonder N2
Adjectival, Descriptions
かけの/かけだ => B in the middle of A; half-A B N3
Time, Situation
はどうあれ => Whatever the A, regardless of the A N1
Based/focused/depending on